Palmitoyl Hexapeptide-12
Symbol Ph · MW 737 Da
Firming cosmetic peptide that mimics elastin signaling.
- Discovered
- 2000
- Half-life
- Unknown
- Approval
- Cosmetic ingredient
Quick facts
- Category
- Beauty
- Route
- Topical
- Molecular weight
- 737 Da
- Half-life
- Unknown
- Discovered
- 2000
- Approval status
- Cosmetic ingredient
Reported effects
- Firming
- Elastin support
- Anti-aging
Overview
Palmitoyl Hexapeptide-12 is a topical cosmetic peptide used in anti-aging and skin-firming formulas. It is commonly associated with improving the appearance of elasticity, smoothness, and skin resilience. The palmitoyl component helps make the peptide more compatible with skincare formulations and may improve how it interacts with the skin barrier. Palmitoyl Hexapeptide-12 is often included in products designed for mature, dry, or weakened-looking skin. As a beauty peptide, its main purpose is to support firmer-looking skin, improved texture, and a healthier skin appearance.
Evidence context
Palmitoyl Hexapeptide-12 evidence summary
Human clinical evidence
Human clinical evidence for Palmitoyl Hexapeptide-12 may be limited, investigational, region-specific, or unavailable in the local source data. Peptidic avoids treating reported effects as proven clinical outcomes.
Animal, preclinical, or formulation evidence
Palmitoyl Hexapeptide-12 is listed in a beauty or cosmetic context, where topical formulation data and ingredient claims should be separated from systemic medical claims.
Status and evidence strength
Peptidic lists the approval status for Palmitoyl Hexapeptide-12 as Cosmetic ingredient. The reported effects below are reference fields from the peptide database, not medical promises. Source links are included later on the page when available so readers can continue review from primary or reputable sources.
How it's taken
- Typical Administration
- Topical
- Typical Dosage
- Common cosmetic concentration is 1–5% depending on formulation
- Typical Frequency
- Once or twice daily
There is no established FDA-approved dosage for this peptide. This information is for educational reference only and should not be treated as medical guidance.
Research sources
Source links included from peer-reviewed literature, clinical records, and medical databases for educational research context on Palmitoyl Hexapeptide-12.
Internal links
Related peptides
Frequently asked questions
What category is Palmitoyl Hexapeptide-12 in?
Palmitoyl Hexapeptide-12 is listed in the Beauty category on Peptidic.
What route is Palmitoyl Hexapeptide-12 associated with?
Palmitoyl Hexapeptide-12 is associated with the topical route in the Peptidic database. This is descriptive route context, not a use instruction.
Is Palmitoyl Hexapeptide-12 approved?
Peptidic lists the approval status for Palmitoyl Hexapeptide-12 as: Cosmetic ingredient. Approval details can vary by indication and jurisdiction.
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For educational purposes only. Many peptides shown are research compounds and not approved for human use in all jurisdictions. Explore the full peptide database, peptide calculator, or peptide tracker.
Last reviewed for educational accuracy: 2026-06-01