Semax
Symbol Sx · MW 814 Da
Heptapeptide ACTH(4-10) analog developed in Russia for cognitive and neuroprotective effects.
- Discovered
- 1982
- Half-life
- 5 minutes
- Approval
- Not FDA-approved in U.S.
Quick facts
- Category
- Mind
- Route
- Nasal
- Molecular weight
- 814 Da
- Half-life
- 5 minutes
- Discovered
- 1982
- Approval status
- Not FDA-approved in U.S.
Reported effects
- Focus & memory
- Neuroprotection
- Mood support
Overview
Semax is a synthetic nootropic peptide associated with focus, memory, mental clarity, neuroprotection, and cognitive performance. It is related to a fragment of ACTH but is designed to focus more on brain-related effects rather than adrenal stimulation. Semax is commonly discussed for attention, learning, mental energy, and neurological recovery research. Its purpose is to support cognitive function, brain resilience, and sharper mental performance. As a mind peptide, Semax is one of the most recognized peptides in the nootropic and brain-health category.
Evidence context
Semax evidence summary
Human clinical evidence
Semax has an approval context listed in the Peptidic database. Approved use still depends on the specific indication, formulation, labeling, and clinician guidance.
Animal, preclinical, or formulation evidence
Semax may be discussed in animal, preclinical, in vitro, or early-stage research contexts. Those evidence types are useful for orientation but should not be treated as equivalent to approved human indications.
Status and evidence strength
Peptidic lists the approval status for Semax as Not FDA-approved in U.S.. The reported effects below are reference fields from the peptide database, not medical promises. Source links are included later on the page when available so readers can continue review from primary or reputable sources.
How it's taken
- Typical Administration
- Nasal
- Typical Dosage
- No established FDA-approved dosage; commonly referenced intranasal range is 300–1000 mcg daily total
- Typical Frequency
- 1–3 times daily
Dosing depends on the approved indication, formulation, titration schedule, and clinician guidance. This page is educational and not a substitute for medical advice.
Research sources
Source links included from peer-reviewed literature, clinical records, and medical databases for educational research context on Semax.
Internal links
Related peptides
Frequently asked questions
What category is Semax in?
Semax is listed in the Mind category on Peptidic.
What route is Semax associated with?
Semax is associated with the nasal route in the Peptidic database. This is descriptive route context, not a use instruction.
Is Semax approved?
Peptidic lists the approval status for Semax as: Not FDA-approved in U.S.. Approval details can vary by indication and jurisdiction.
Interested in Semax?
Enter your email and we'll send our recommended peptide vendor for educational research reference.
Review the peptide vendor research checklistEducational reference only · No spam · Unsubscribe anytime
For educational purposes only. Many peptides shown are research compounds and not approved for human use in all jurisdictions. Explore the full peptide database, peptide calculator, or peptide tracker.
Last reviewed for educational accuracy: 2026-06-01