Matrixyl
Symbol Mx · MW 802 Da
Palmitoyl pentapeptide used in topical anti-wrinkle formulations.
- Discovered
- 2000
- Half-life
- 2-30 minutes
- Approval
- Cosmetic ingredient
Quick facts
- Category
- Beauty
- Route
- Topical
- Molecular weight
- 802 Da
- Half-life
- 2-30 minutes
- Discovered
- 2000
- Approval status
- Cosmetic ingredient
Reported effects
- Wrinkle reduction
- Collagen support
- Skin firmness
Overview
Matrixyl, also known as Palmitoyl Pentapeptide, is a topical signal peptide used in anti-aging skincare products. Signal peptides are designed to support the appearance of collagen production and extracellular matrix repair, which are important for firmness and smoothness. Matrixyl is commonly used in serums, creams, and wrinkle treatments to reduce the appearance of fine lines and improve skin texture over time. It is often positioned as a gentler alternative to harsher anti-aging ingredients. As a beauty peptide, Matrixyl is best known for collagen support, wrinkle reduction, and firmer-looking skin.
Evidence context
Matrixyl evidence summary
Human clinical evidence
Human clinical evidence for Matrixyl may be limited, investigational, region-specific, or unavailable in the local source data. Peptidic avoids treating reported effects as proven clinical outcomes.
Animal, preclinical, or formulation evidence
Matrixyl is listed in a beauty or cosmetic context, where topical formulation data and ingredient claims should be separated from systemic medical claims.
Status and evidence strength
Peptidic lists the approval status for Matrixyl as Cosmetic ingredient. The reported effects below are reference fields from the peptide database, not medical promises. Source links are included later on the page when available so readers can continue review from primary or reputable sources.
How it's taken
- Typical Administration
- Topical
- Typical Dosage
- Common cosmetic-use range is low ppm to several percent depending on raw material concentration and finished formula
- Typical Frequency
- Once or twice daily
There is no established FDA-approved dosage for this peptide. This information is for educational reference only and should not be treated as medical guidance.
Research sources
Source links included from peer-reviewed literature, clinical records, and medical databases for educational research context on Matrixyl.
Internal links
Related peptides
Frequently asked questions
What category is Matrixyl in?
Matrixyl is listed in the Beauty category on Peptidic.
What route is Matrixyl associated with?
Matrixyl is associated with the topical route in the Peptidic database. This is descriptive route context, not a use instruction.
Is Matrixyl approved?
Peptidic lists the approval status for Matrixyl as: Cosmetic ingredient. Approval details can vary by indication and jurisdiction.
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For educational purposes only. Many peptides shown are research compounds and not approved for human use in all jurisdictions. Explore the full peptide database, peptide calculator, or peptide tracker.
Last reviewed for educational accuracy: 2026-06-01