Argireline
Symbol Ag · MW 889 Da
Acetyl hexapeptide that softens expression-line muscle activity topically.
- Discovered
- 2002
- Half-life
- 5 days
- Approval
- Cosmetic ingredient
Quick facts
- Category
- Beauty
- Route
- Topical
- Molecular weight
- 889 Da
- Half-life
- 5 days
- Discovered
- 2002
- Approval status
- Cosmetic ingredient
Reported effects
- Expression line softening
- Topical use
- Smoothing
Overview
Argireline, also known as Acetyl Hexapeptide-8, is a topical anti-aging peptide commonly used to reduce the appearance of expression lines and fine wrinkles. It is often compared to Botox in marketing because it targets the look of lines caused by repeated facial movement, but it works much more mildly and topically. Argireline is commonly found in wrinkle serums, eye creams, and facial treatments aimed at the forehead, crow's feet, and smile lines. Its purpose is to help the skin appear smoother, more relaxed, and less creased over time. As a skincare peptide, Argireline is popular for non-invasive wrinkle care and expression-line support.
Evidence context
Argireline evidence summary
Human clinical evidence
Human clinical evidence for Argireline may be limited, investigational, region-specific, or unavailable in the local source data. Peptidic avoids treating reported effects as proven clinical outcomes.
Animal, preclinical, or formulation evidence
Argireline is listed in a beauty or cosmetic context, where topical formulation data and ingredient claims should be separated from systemic medical claims.
Status and evidence strength
Peptidic lists the approval status for Argireline as Cosmetic ingredient. The reported effects below are reference fields from the peptide database, not medical promises. Source links are included later on the page when available so readers can continue review from primary or reputable sources.
How it's taken
- Typical Administration
- Topical
- Typical Dosage
- Common cosmetic concentration is 5–10%
- Typical Frequency
- Once or twice daily
There is no established FDA-approved dosage for this peptide. This information is for educational reference only and should not be treated as medical guidance.
Research sources
Source links included from peer-reviewed literature, clinical records, and medical databases for educational research context on Argireline.
Internal links
Related peptides
Frequently asked questions
What category is Argireline in?
Argireline is listed in the Beauty category on Peptidic.
What route is Argireline associated with?
Argireline is associated with the topical route in the Peptidic database. This is descriptive route context, not a use instruction.
Is Argireline approved?
Peptidic lists the approval status for Argireline as: Cosmetic ingredient. Approval details can vary by indication and jurisdiction.
Interested in Argireline?
Enter your email and we'll send our recommended peptide vendor for educational research reference.
Review the peptide vendor research checklistEducational reference only · No spam · Unsubscribe anytime
For educational purposes only. Many peptides shown are research compounds and not approved for human use in all jurisdictions. Explore the full peptide database, peptide calculator, or peptide tracker.
Last reviewed for educational accuracy: 2026-06-01