Acetyl Tetrapeptide-5
Symbol A5 · MW 493 Da
Topical tetrapeptide formulated for under-eye puffiness.
- Discovered
- 2003
- Half-life
- 2-30 minutes
- Approval
- Cosmetic ingredient
Reported effects
- Reduces eye bags
- De-puffing
- Microcirculation
Overview
Acetyl Tetrapeptide-5 is a topical skincare peptide commonly used in eye creams, serums, and anti-aging formulas. It is most often associated with reducing the appearance of under-eye puffiness, tired-looking skin, and fluid-related swelling around the eyes. This peptide is used in cosmetic formulations to support smoother, firmer, and more refreshed-looking skin. It does not physically remove under-eye bags, but it may help improve the appearance of temporary puffiness and skin fatigue. As a beauty peptide, Acetyl Tetrapeptide-5 is best known for under-eye care, skin smoothing, and visible puffiness reduction.
How it's taken
- Typical Administration
- Topical
- Typical Dosage
- Cosmetic-use concentration commonly around 0.01% in tested formulas; commercial ranges vary
- Typical Frequency
- Once or twice daily
Research sources
Source links included from peer-reviewed literature and trusted medical journal records for this peptide.
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For educational purposes only. Many peptides shown are research compounds and not approved for human use in all jurisdictions.