Acetyl Tetrapeptide-5
Symbol A5 · MW 493 Da
Topical tetrapeptide formulated for under-eye puffiness.
- Discovered
- 2003
- Half-life
- 2-30 minutes
- Approval
- Cosmetic ingredient
Quick facts
- Category
- Beauty
- Route
- Topical
- Molecular weight
- 493 Da
- Half-life
- 2-30 minutes
- Discovered
- 2003
- Approval status
- Cosmetic ingredient
Reported effects
- Reduces eye bags
- De-puffing
- Microcirculation
Overview
Acetyl Tetrapeptide-5 is a topical skincare peptide commonly used in eye creams, serums, and anti-aging formulas. It is most often associated with reducing the appearance of under-eye puffiness, tired-looking skin, and fluid-related swelling around the eyes. This peptide is used in cosmetic formulations to support smoother, firmer, and more refreshed-looking skin. It does not physically remove under-eye bags, but it may help improve the appearance of temporary puffiness and skin fatigue. As a beauty peptide, Acetyl Tetrapeptide-5 is best known for under-eye care, skin smoothing, and visible puffiness reduction.
Evidence context
Acetyl Tetrapeptide-5 evidence summary
Human clinical evidence
Human clinical evidence for Acetyl Tetrapeptide-5 may be limited, investigational, region-specific, or unavailable in the local source data. Peptidic avoids treating reported effects as proven clinical outcomes.
Animal, preclinical, or formulation evidence
Acetyl Tetrapeptide-5 is listed in a beauty or cosmetic context, where topical formulation data and ingredient claims should be separated from systemic medical claims.
Status and evidence strength
Peptidic lists the approval status for Acetyl Tetrapeptide-5 as Cosmetic ingredient. The reported effects below are reference fields from the peptide database, not medical promises. Source links are included later on the page when available so readers can continue review from primary or reputable sources.
How it's taken
- Typical Administration
- Topical
- Typical Dosage
- Cosmetic-use concentration commonly around 0.01% in tested formulas; commercial ranges vary
- Typical Frequency
- Once or twice daily
There is no established FDA-approved dosage for this peptide. This information is for educational reference only and should not be treated as medical guidance.
Research sources
Source links included from peer-reviewed literature, clinical records, and medical databases for educational research context on Acetyl Tetrapeptide-5.
Internal links
Related peptides
Frequently asked questions
What category is Acetyl Tetrapeptide-5 in?
Acetyl Tetrapeptide-5 is listed in the Beauty category on Peptidic.
What route is Acetyl Tetrapeptide-5 associated with?
Acetyl Tetrapeptide-5 is associated with the topical route in the Peptidic database. This is descriptive route context, not a use instruction.
Is Acetyl Tetrapeptide-5 approved?
Peptidic lists the approval status for Acetyl Tetrapeptide-5 as: Cosmetic ingredient. Approval details can vary by indication and jurisdiction.
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For educational purposes only. Many peptides shown are research compounds and not approved for human use in all jurisdictions. Explore the full peptide database, peptide calculator, or peptide tracker.
Last reviewed for educational accuracy: 2026-06-01