Sermorelin
Symbol Sm · MW 3358 Da
Truncated GHRH that stimulates pituitary GH release.
- Discovered
- 1984
- Half-life
- 12 minutes
- Approval
- Compounded clinical use
Quick facts
- Category
- Hormone
- Route
- Injectable
- Molecular weight
- 3358 Da
- Half-life
- 12 minutes
- Discovered
- 1984
- Approval status
- Compounded clinical use
Reported effects
- GH stimulation
- Sleep quality
- Recovery
Overview
Sermorelin is a synthetic growth hormone-releasing hormone peptide that stimulates the pituitary gland to release natural growth hormone. It is often used in discussions about hormone optimization, recovery, sleep quality, body composition, and age-related GH decline. Compared with longer-acting peptides like CJC-1295 with DAC, Sermorelin has a shorter half-life and more closely mimics natural GH-releasing signals. Its purpose is to support the body's own growth hormone production rather than directly replacing growth hormone. As a hormone peptide, Sermorelin is commonly associated with natural GH stimulation and endocrine support.
Evidence context
Sermorelin evidence summary
Human clinical evidence
Human clinical evidence for Sermorelin may be limited, investigational, region-specific, or unavailable in the local source data. Peptidic avoids treating reported effects as proven clinical outcomes.
Animal, preclinical, or formulation evidence
Sermorelin may be discussed in animal, preclinical, in vitro, or early-stage research contexts. Those evidence types are useful for orientation but should not be treated as equivalent to approved human indications.
Status and evidence strength
Peptidic lists the approval status for Sermorelin as Compounded clinical use. The reported effects below are reference fields from the peptide database, not medical promises. Source links are included later on the page when available so readers can continue review from primary or reputable sources.
How it's taken
- Typical Administration
- Injectable
- Typical Dosage
- No established general wellness dosage; commonly referenced range is 100–500 mcg
- Typical Frequency
- Once daily, commonly before sleep
There is no established FDA-approved dosage for this peptide. This information is for educational reference only and should not be treated as medical guidance.
Research sources
Source links included from peer-reviewed literature, clinical records, and medical databases for educational research context on Sermorelin.
Internal links
Related peptides
Frequently asked questions
What category is Sermorelin in?
Sermorelin is listed in the Hormone category on Peptidic.
What route is Sermorelin associated with?
Sermorelin is associated with the injectable route in the Peptidic database. This is descriptive route context, not a use instruction.
Is Sermorelin approved?
Peptidic lists the approval status for Sermorelin as: Compounded clinical use. Approval details can vary by indication and jurisdiction.
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For educational purposes only. Many peptides shown are research compounds and not approved for human use in all jurisdictions. Explore the full peptide database, peptide calculator, or peptide tracker.
Last reviewed for educational accuracy: 2026-06-01