MOTS-c
Symbol Mt · MW 2175 Da
Mitochondrial-derived peptide regulating metabolic homeostasis.
- Discovered
- 2015
- Half-life
- 2-4 hours
- Approval
- Not FDA-approved
Quick facts
- Category
- Longevity
- Route
- Injectable
- Molecular weight
- 2175 Da
- Half-life
- 2-4 hours
- Discovered
- 2015
- Approval status
- Not FDA-approved
Reported effects
- Insulin sensitivity
- Endurance
- Mitochondrial health
Overview
MOTS-c is a mitochondrial-derived peptide involved in energy metabolism, metabolic regulation, and cellular stress response. Because mitochondria are responsible for producing cellular energy, MOTS-c is commonly discussed in relation to longevity, exercise performance, insulin sensitivity, and metabolic health. It is studied for its potential role in supporting mitochondrial function and improving the body's response to metabolic stress. MOTS-c is often categorized as a longevity peptide because mitochondrial health is closely connected to aging, energy production, and overall cellular resilience. Its purpose is to support metabolic flexibility, mitochondrial function, and healthy aging research.
Evidence context
MOTS-c evidence summary
Human clinical evidence
MOTS-c has an approval context listed in the Peptidic database. Approved use still depends on the specific indication, formulation, labeling, and clinician guidance.
Animal, preclinical, or formulation evidence
MOTS-c may be discussed in animal, preclinical, in vitro, or early-stage research contexts. Those evidence types are useful for orientation but should not be treated as equivalent to approved human indications.
Status and evidence strength
Peptidic lists the approval status for MOTS-c as Not FDA-approved. The reported effects below are reference fields from the peptide database, not medical promises. Source links are included later on the page when available so readers can continue review from primary or reputable sources.
How it's taken
- Typical Administration
- Injectable
- Typical Dosage
- No established approved dosage; commonly referenced range is 5–15 mg per injection
- Typical Frequency
- 2–3 times weekly
Dosing depends on the approved indication, formulation, titration schedule, and clinician guidance. This page is educational and not a substitute for medical advice.
Research sources
Source links included from peer-reviewed literature, clinical records, and medical databases for educational research context on MOTS-c.
Internal links
Related peptides
Frequently asked questions
What category is MOTS-c in?
MOTS-c is listed in the Longevity category on Peptidic.
What route is MOTS-c associated with?
MOTS-c is associated with the injectable route in the Peptidic database. This is descriptive route context, not a use instruction.
Is MOTS-c approved?
Peptidic lists the approval status for MOTS-c as: Not FDA-approved. Approval details can vary by indication and jurisdiction.
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For educational purposes only. Many peptides shown are research compounds and not approved for human use in all jurisdictions. Explore the full peptide database, peptide calculator, or peptide tracker.
Last reviewed for educational accuracy: 2026-06-01